VCU Department of Radiology

Normal bone development depends on ready availability of calcium, phosphorus and vitamin D.
Rickets is a consequence of decreased availability of these substances.
Calcium and Phosphorus is essential for formation of hydroxyapatite crystals.
Vitamin D promotes calcium absorption from intestine, calcium resorption from proximal renal tubules, regulates apoptosis of chondrocytes, mineralization of cartilage matrix and metaphyseal angiogenesis.
Widening and irregularity of the growth plate-Fraying
Widening of the metaphyseal end of bone-Splaying
Concavity of the metaphysis-Cupping
Medications causing Rickets: Dilantin
 Ifosfamide
Oncogenic Rickets-Paraneoplastic syndromes that has been reported with non-ossifying fibroma,hemangiopericytoma,osteoblastoma and linear sebaceous nevus syndrome