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Answer to Case of the Week: Dec 10-Dec 17, 2009

2 month old with palpable mass.Pleasse give two possible differential diagnosis?


 




Abdominal radiograph shows a left upper quadrant mass displacing the stomach. MR demonstrate a mass which is high in signal peripherally on T2, very low in signal centrally on T1, and enhances peripherally on post-Gd images. The mass arises from the left lobe of the liver.

Diagnosis: Hemangioendothelioma

The two most common lesions in the liver in childhood are hepatoblastoma and infantile hemangioendothelioma.

 Both occur in young children and it is not always possible to differentiate between the two.

 A clue in this patient (not told) is a low alpha fetoprotein.

     Hepatoblastomas occur in patients usually under two years of age and may present with a mass, pain, weight loss or precocious puberty due to chorionic gonadotropin production by the tumor.
    Infantile hemangioendothelioma occurs in children usually under 6 months of age and may be solitary or diffuse in the liver.  

 A clue may be heart failure due to increased flow.


Both may appear solid on ultrasound, contain calcium and undergo peripheral enhancement.

   The hemangioendothelioma undergoes peripheral fill-in over time.
The other lesions that occurs in young children are mesenchymal hamartoma, which is central and based in the porta hepatis and sarcoma, which cannot be distinguished.


Biopsy is need for specific diagnosis of liver lesions in children.

Biopsy confirmed diagnosis and mass is decreasing in size being treated with steroid and interferon on follow up studies. 



Residents Submitting Correct Diagnosis - Case of the Week
Radiology
Pediatrics
VCU Resident
  • Judson Frye
  • Aaron Nordgren
  • Todd Berry
  • Mónica Fdez.
  • Jamil Muasher
  • Shep Morano
  • Brian Deuell
    Others
  • Nicole KelleherUnited States of America
  • Wael NemattallaEgypt
  • Gitanjali BajajIndia
  • JAMAL ABAZIDSyrian Arab Republic
  • Saeed NihayahSaudi Arabia
  • Cephus SimmonsUnited States of America
  • Monika BagadeIndia
  • Joshua BallUnited States of America
  • Mantosh RattanUnited States of America
  • Hari NadendlaIndia
  • Shanaree MuzinichUnited States of America
  • Kavitha GanesanIndia
  • Sema YildizTurkey
  • Ankireddy PadmajaIndia
  • Syed AminUnited States of America
  • Matt GipsonUnited States of America
  • Ravindra PatilIndia
  • Clint JokerstUnited States of America
  • Alok SaoIndia
  • Simon DupreAustralia
  • Bala ChandranIndia
  • Dala ZakariaUnited States of America
  • Pankaj AgarwalIndia
  • Carolyn WassongUnited States of America
  • Waleed MarzokSaudi Arabia
  • Rajesh PahwaIndia

    Disclaimer: This information is intended solely for resident review of presented cases which may or may not be pathologically proven. Information is derived from a number of published sources of varying reliability and does not represent original research from the institution. It is not intended to be comprehensive and should therefore not substitute for careful review of the literature.