Pediatric Case of the Week:  August 20-August 27, 2008
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16 year old male with Gardners syndrome, prior adeno CA

Give most likely etiology of finding.

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Answer to Case of the Week: Aug 13-Aug 20, 2008

5 different patients with same diagnosis


Clefts in the brain parenchyma that extend from the cortical surface to the ventricle (pia to ependyma) lined by dysplastic gray matter.

Diagnosis: SCHIZENCEPHALY

Frontal and parietal lobes near central sulcus is the most common location.

Closed lip lesions are small, with walls apposed to each other.

Open lip lesions can be very large mimicking hydranencephaly.

50% are bilateral.

Can be due to acquired insult or inherited mutation.

Intrauterine insults include CMV, maternal trauma or toxin exposure.

 

Differential Diagnosis:

Porencephaly-Lined by gliotic white matter

Hydranencephaly

Semi lobar Holoprosencephaly

Agenesis of corpus callosum with interhemispheric cyst

 

Dimple in wall of lateral ventricle-look for closed lip schizencephaly.

Angle of wall-PVL

Lump on wall-GM heterotopia or subependymal nodules of Tuberous sclerosis.

 


Residents Submitting Correct Diagnosis - Case of the Week
Radiology
Pediatrics
VCU Resident
  • Dishant Shah
  • John Kirkham
  • Maria Torrone
  • Arash Chehrazi
  • Kenny Uy
  • David Polinger-Hyman
    Others
  • Roja TummaIndia
  • Hani SharkeyUnited States of America
  • Nagendar RaoIndia
  • Yeshodha YennaIndia
  • Gitanjali BajajIndia
  • Zorez KamranPakistan
  • Jamal AbazidSaudi Arabia
  • Raghu MurthyIndia
  • Joshua BallUnited States of America


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