Frontal and parietal lobes near central sulcus is the most common location.
Closed lip lesions are small, with walls apposed to each other.
Open lip lesions can be very large mimicking hydranencephaly.
50% are bilateral.
Can be due to acquired insult or inherited mutation.
Intrauterine insults include CMV, maternal trauma or toxin exposure.
Differential Diagnosis:
Porencephaly-Lined by gliotic white matter
Hydranencephaly
Semi lobar Holoprosencephaly
Agenesis of corpus callosum with interhemispheric cyst
Dimple in wall of lateral ventricle-look for closed lip schizencephaly.
Angle of wall-PVL
Lump on wall-GM heterotopia or subependymal nodules of Tuberous sclerosis.